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Kobak, Kenneth A., James C. Mundt, John H. Greist,
David J. Katzelnick, James W. Jefferson: Computer Assessment of
Depression: Automating the Hamilton Depression Rating Scale. Drug
Information Journal 34 (1): 145-156, 2000.
Current clinical computing systems have evolved
over the past three decades and can now be implemented from any
touch-tone telephone using interactive voice response (IVR) technology,
permitting accessibility 24 hours a day, 7 days a week. Ten years
of research and development investigating computer automation of
the Hamilton Depression Rating Scale (HDRS), involving 10 separate
studies and 1761 subjects, shows strong correspondence with clinician-administered
assessments. The psychometric properties concerning assessment reliability
and validity of clinician- and computer-administered versions of
the HDRS are compared and points of divergence between methods drawn
from a recently completed clinical trial are discussed. Future challenges
facing expanded use of such clinical computing systems in clinical
trials of investigational drugs are also discussed.
Key Words: Interactive
Voice Response (IVR); Clinical assessment; Depression; Electronic
data capture
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